First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
PHARMACY
Course unit
DRUG DELIVERY AND TARGETING
MEP3051857, A.A. 2018/19

Information concerning the students who enrolled in A.Y. 2014/15

Information on the course unit
Degree course 5 years single cycle degree in
PHARMACY (Ord. 2009)
FA1732, Degree course structure A.Y. 2009/10, A.Y. 2018/19
N0
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination DRUG DELIVERY AND TARGETING
Department of reference Department of Pharmaceutical and Pharmacological Sciences
Mandatory attendance
Language of instruction Italian
Branch PADOVA
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Lecturers
Teacher in charge ODDONE SCHIAVON CHIM/09

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses CHIM/09 Applied Technological Pharmaceutics 6.0

Course unit organization
Period First semester
Year 5th Year
Teaching method frontal

Type of hours Credits Teaching
hours
Hours of
Individual study
Shifts
Lecture 6.0 48 102.0 No turn

Calendar
Start of activities 01/10/2018
End of activities 18/01/2019
Show course schedule 2019/20 Reg.2018 course timetable

Examination board
Board From To Members of the board
7 Commissione a.a. 2019/20 02/12/2019 30/09/2020 SCHIAVON ODDONE (Presidente)
PASUT GIANFRANCO (Membro Effettivo)

Syllabus
Prerequisites: Prerequisites are not foreseen, but the student is advised to attend the course and take the exam only after having attended and/or taken the examinations of the first three years.
Target skills and knowledge: The aim of the course is to provide knowledge in the field of innovative pharmaceutical forms technology, with particular regard to the design of drug delivery systems for a controlled and specific site delivery of low and high molecular weight drugs.
Examination methods: The exam includes a written test on topics covered in class and in any case related to the teaching program.
The student will be offered two topics, which she/he will have to develop in the two and a half hours.
The test aims to ascertain whether the student has acquired the knowledge on the design and implementation of innovative pharmaceutical forms for a controlled and sito-specific release of the drug.
Assessment criteria: The assessment of the student's preparation will be based on understanding and the ability to critically and consciously apply the arguments developed.
Course unit contents: Polymers of pharmaceutical interest: general aspects, classification. Polymerization reactions. Polymers of synthetic and natural origin. Physical properties of polymers: numerical and weight average molecular weight. Experimental methods for the determination of molecular weight. Polydispersity. Fractionation of polymers. Drug release from polymeric systems for diffusion mechanisms, for chemical control and for solvent intervention. Smart polymers. Biodegradable and non-biodegradable polymers. Dendrimers. Polymeric micelles. Pharmaceutical systems for drug delivery. Passive "Targeting". "Targeting" active, directing molecules (folate, RGD, galactosamine, antibodies, etc.). Polymeric bioconjugates. Endocytosis. EPR effect Pro-polymeric drugs. Polymer-drug conjugates on the market and in advanced clinical trials. Drugs of biotechnology origin: stability, formulation strategies, conservation. Incorporation into particle carriers. Surface modification with polymers. "Polymer-protein conjugates" on the market and in advanced clinical trials. Liposomes: general aspects, preparation and use as a "carrier" to direct drugs at the site of action.
Planned learning activities and teaching methods: Teaching consists of lectures, during which slides and videos will be projected to make the contents of the lessons more interesting and clear.
For each theme are prepared handouts containing notes and slides that are delivered to students before their discussion in class.
Additional notes about suggested reading: Since there is no single reference text, for the preparation of the exam the student will have to use the notes taken in class and the material delivered by the teacher.
Furthermore, the following texts are available for consultation, available in the library of the Department of Pharmaceutical Sciences: E. Quagliarello, F. Calmieri, Drug carrier systems, ed. F.H. Roerdink, A:M: Kroon; P. Johnson, J.G. Lloyd-Jones, Drug delivery systems, ed. Horwood, Chichester; Praveen Tyle-Bhanu P. Ram, Targeted therapeutic system; L.F. Prescott, W.S. Nimmo, Novel drug delivery, ed. John Wiley and Sons, Chichester.P. Colombo et al Principi di tecnologie farmaceutiche. Casa Ed. Ambrosiana. M. Amorosa, Principi di Tecnica Farmaceutica, ed. Libreria Universitaria L. Tinarelli, Bologna;A.T. Florence, D. Attwood, Le basi chimico-fisiche della Tecnologia Farmaceutica, Ed.EdiSES. Peptide and Protein Drug Delivery edited by Vincent H. L. Lee; J.W. Nicholson, The chemistry of Polymers.
Textbooks (and optional supplementary readings)

Innovative teaching methods: Teaching and learning strategies
  • Case study
  • Questioning
  • Problem solving
  • Use of online videos

Innovative teaching methods: Software or applications used
  • Moodle (files, quizzes, workshops, ...)

Sustainable Development Goals (SDGs)
Good Health and Well-Being Industry, Innovation and Infrastructure