First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
Course unit
MEP3051825, A.A. 2018/19

Information concerning the students who enrolled in A.Y. 2014/15

Information on the course unit
Degree course 5 years single cycle degree in
PHARMACY (Ord. 2009)
FA1732, Degree course structure A.Y. 2009/10, A.Y. 2018/19
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination PHARMACEUTICAL BIOTECHNOLOGIES
Department of reference Department of Pharmaceutical and Pharmacological Sciences
E-Learning website
Mandatory attendance
Language of instruction Italian
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Teacher in charge LISA DALLA VIA CHIM/08

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses CHIM/08 Pharmaceutical Chemistry 6.0

Course unit organization
Period First semester
Year 5th Year
Teaching method frontal

Type of hours Credits Teaching
Hours of
Individual study
Lecture 6.0 48 102.0 No turn

Start of activities 01/10/2018
End of activities 18/01/2019
Show course schedule 2019/20 Reg.2018 course timetable

Examination board
Board From To Members of the board
7 Commissione a.a. 2019/20 02/12/2019 30/09/2020 DALLA VIA LISA (Presidente)
MIOLO GIORGIA (Membro Effettivo)
SISSI CLAUDIA (Membro Effettivo)
6 Commissione a.a. 2018/19 03/12/2018 30/09/2019 DALLA VIA LISA (Presidente)
MIOLO GIORGIA (Membro Effettivo)
SISSI CLAUDIA (Membro Effettivo)
5 Commissione a.a. 2017/18 01/12/2017 27/11/2018 DALLA VIA LISA (Presidente)
MIOLO GIORGIA (Membro Effettivo)
SISSI CLAUDIA (Membro Effettivo)

Prerequisites: Knowledge on cell biology, pathology and microbiology are needed.
Target skills and knowledge: The main biotechnological techniques and the most important classes of biopharmaceuticals approved in therapy or in advanced clinical trials, will be treated.
Examination methods: An oral examination will be taken to demonstrate the knowledge of both the biotechnological techniques and biopharmaceuticals.
Assessment criteria: The objective is to test the student’s ability to understand the principles of the pharmaceutical biotechnologies and to knowledge the biopharmaceuticals with particular attention to the differences with respect to conventional drugs.
Course unit contents: The content of the course is divided in two parts: in the first one the most used biothecnologies will be discussed, in the second part the biopharmaceuticals or the classes of biopharmaceuticals most important from a therapeutic point of view will be described.
The topics of the first part will be:
- recombinant DNA technology: vectors, restriction enzymes, transformation, insertional inactivation. Examples of drugs prepared by recombinant DNA technology.
- DNA sequencing: chemical and enzymatic methods.
- Polymerase chain reaction.
- Nucleic acid technologies: antisense, triple helix, aptamers and ribozymes. Examples of drugs prepared by nucleic acid technologies.
- Hybridoma technology for antibody production. Chimeric, humanized and human monoclonal antibodies: phage display and knockout mouse.
- Glycotechnology: native and modified erythropoietin, heparins.
- Gene therapy. Viral and non-viral vectors. Retrovirus, adenovirus and adenovirus-associated. Diseases targeted by gene therapy and clinical trials.
In the second part of the course the following biopharmaceuticals will be described:
- cytokines: interleukins and interferons.
- Hormons: native and genetically engineered insulin, growth hormon.
- Monoclonal antibodies in anticancer, immunosuppressive and antiviral therapy.
- Enzymes: native and recombinat tissue plasminogen activator, human recombinant DNAse.
Planned learning activities and teaching methods: Frontal lecturing with audiovisual supports (mainly slides) available on MOODLE platform.
Additional notes about suggested reading: Student notes are fundamental, supported by the texts indicated below.
Textbooks (and optional supplementary readings)
  • G. Walsh, Biopharmaceuticals. Biochemistry and Biotechnology. --: Wiley, --. testo di studio Cerca nel catalogo
  • M.L. Calabrò, Compendio di Biotecnologie Farmaceutiche. --: EdiSES, --. testo di studio Cerca nel catalogo
  • R. D. Sindelar, Crommelin D.J.A., Pharmaceutical Biotechnology. --: Informa Healthcare, --. testo di studio Cerca nel catalogo

Innovative teaching methods: Teaching and learning strategies
  • Lecturing
  • Interactive lecturing
  • Loading of files and pages (web pages, Moodle, ...)

Innovative teaching methods: Software or applications used
  • Moodle (files, quizzes, workshops, ...)

Sustainable Development Goals (SDGs)
Good Health and Well-Being