First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Agricultural Sciences and Veterinary Medicine
ANIMAL SCIENCE AND TECHNOLOGY
Course unit
BIOCHEMISTRY
AGN1029471, A.A. 2013/14

Information concerning the students who enrolled in A.Y. 2013/14

Information on the course unit
Degree course First cycle degree in
ANIMAL SCIENCE AND TECHNOLOGY (Ord. 2013)
IF0325, Degree course structure A.Y. 2013/14, A.Y. 2013/14
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Number of ECTS credits allocated 6.0
Course unit English denomination BIOCHEMISTRY
Website of the academic structure http://www.unipd.it/corsi/corsi-di-laurea/corsi-di-laurea/corsi-di-laurea-agraria/scienze-e-tecnologie-animali
Department of reference Department of Agronomy, Food, Natural Resources, Animals and the Environment
Mandatory attendance No
Language of instruction Italian
Branch LEGNARO (PD)

Lecturers
Teacher in charge ALESSANDRO NEGRO BIO/10

Integrated course for this unit
Course unit code Course unit name Teacher in charge
AGN1029469 GENERAL AND INORGANIC CHEMISTRY AND BIOCHEMISTRY ALESSANDRO NEGRO

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses BIO/10 Biochemistry 6.0

Course unit organization
Period First semester
Year 1st Year
Teaching method frontal

Type of hours Credits Teaching
hours
Hours of
Individual study
Shifts
Lecture 6.0 48 102.0 No turn

Calendar
Start of activities 01/10/2013
End of activities 25/01/2014
Show course schedule 2019/20 Reg.2017 course timetable

Examination board
Board From To Members of the board
17/12/2012 30/11/2013 NEGRO ALESSANDRO (Presidente)

Syllabus

Common characteristics of the Integrated Course unit

Prerequisites: No specific pass of these exams are required.
Target skills and knowledge: Through theoretical lectures and practical exercises, students will acquire know-how on fundamental chemistry. The resolution of numerical exercises will also make the student familiar with a scientific approach towards various topics. Gaining knowledge on the structure and function relationships in biological macromolecules, on the metabolism and the strategies of metabolic regulation.
Examination methods: The examination of students will be carried out through written tests accounting for numerical exercises and questions to be answered with a brief text production.
Assessment criteria: Student knowledge will be evaluated considering both specific definitions provided during the course, and also evaluating the capacity of using the acquired know-how in the solution of general and inorganic chemistry numerical problems. The biochemistry knowledge will be evaluated considering both specific definitions given during the course but also by analyzing their capacity of applying the acquired knowledge in integrate manner

Specific characteristics of the Module

Course unit contents: Atomic structure. Building up the periodic table and periodic properties. Chemical bonding: ionic, metallic and covalent bonds. Lewis formulas. Matter aggregation states and related phase transitions. The gaseous state. Kinetic theory of gases: the basics. Real gases. Intermolecular forces. The solid state: basic information on the main structures and properties. The liquid state: main characteristics. Solutions: properties and composition. Concentration and related units. Colligative properties.Thermodynamics. State Functions: The First and Second Thermodynamics Principle. Reversible and irreversible processes. Gibbs energy and spontaneous reactions. Chemical Kinetics: the basics. Reaction rate and rate constant.Catalysis.Chemical equilibria. The law of mass action and equilibrium constants. Homogeneous and heterogeneous equilibria. Le Chatelier principle.Equilibria in aqueous solutions: acids and bases. pH and acidity scale. Strong and weak acids and bases. Hydrolysis reactions and buffer solutions. Titrations. Precipitation equilibria of sparingly soluble salts and hydroxides. Common ion effect.Electrochemistry: Galvanic cells and standard potentials. Nernst equation. Electrolysis and electrolytic conduction. Applications. Examples. Carbohydrates: Monosaccarides, Disaccarides Sucrose e Lactose, Polysaccarides, Starch and Cellulose, Jaluronic acid, Heparin. Lipid: Fatty Acid, Triglicerides, Phosphoglicerides, colesterol, Biological Membrane. Amino acid e Protein Structure Amino acid classification. Primary, Secondary tertiary and Quaternary structure of proteins. Structure and function relationships in proteins and enzymes. Enzymes: mechanisms of catalysis, Michaelis-Menten kinetic, kinetic parameters, activators and inhibitors. Mechanisms of regulations. allosteric enzymes. Mioglobin, hemoglobin. Heme-globin bond, ossigenation, cooperativity, allosteric effectors and the Bohr effect.Bioenergetics.Carbohydrates and lipids metabolism: Transformation of energy during the metabolism. Esergonic and endergonic reactions, coupled reactions. Anabolism and catabolism. High energy compounds relevant to biochemistry. ATP. Substrate-level phosphorylation. The biological oxidation reactions. Structure and function of the respiratory chain. Oxidative phosphorylation in mitochondria and chemiosmotic mechanism of coupling. Physiologically relevant carbohydrates. Glucose metabolism and its regulation: glycolysis, pentose phosphate pathway, Krebs cycle. Gluconeogenesis. Glycogen metabolism. Physiologically relevant lipids. Lipid metabolism and its regulation: fatty acid biosynthesis, elongation, desaturation; Plasma lipoproteins: classification, structure, function, analysis. Digestion of lipids and chilomicrons formation. Metabolism of lipoproteins. Adipose tissue biochemistry, lipogenesis and lipolysis. fatty acids activation and oxidation. Mechanisms of fatty acid oxidation ketogenesis and ketone bodies utilization. Propionic acid utilization. Relationships between lipid and carbohydrate metabolism: role of the metabolic hormones and the tissues. Metabolism of proteins aminoacids Protein turnover. Alpha aminic nitrogen fate: deamination, transamination, glutamine synthesis, urea cycle. Catabolism of the carbon backbone of aminoacids. Hormones classification and general mechanisms of action. Cell surface and intracellular receptors. Intracellular messengers: cAMP and adenylate cyclase system, protein kinases and phosphatases, cGMP, phosphatidylinositols and Ca2+. Nitric oxide: synthesis and action mechanisms. Receptors with tyrosine kinase activity, insulin receptor. Steroid hormones receptors and action mechanisms.
Planned learning activities and teaching methods: Direct teaching activity, through informatics instruments and lectures/exercises on the blackboard, on the fundamental concepts of general and inorganic chemistry e della Biochimica. Lessons will start with the easiest topics, such as compound formula and names, up to Lewis structures, acid-base equilibria, electrochemistry until of relationship of methabolism. Exercises will be performed with the aim of providing the course with practical contents and giving them the chance to become technicians able to handle the fundamental chemistry elements needed in future career.
Additional notes about suggested reading: The presence of students during direct teaching activities are strictly recommended in order to acquire the material presented during lectures. At the end of each lectures the teaching will allow the students to access to slide material in pdf format.
Textbooks (and optional supplementary readings)
  • Jeremy M. Berg, John L. Tymoczko, Lubert Stryer, Biochimica. --: Zanichelli, 2012. Cerca nel catalogo
  • David L. Nelson, Michael M. Cox, I principi di biochimica di Lehninger. --: Zanichelli, 2010. Cerca nel catalogo
  • Fondamenti di biochimica, Donald Voet, Judith G. Voet, Charlotte W. Pratt. --: Zanichelli, 2013.
  • A. Peloso, F. De Martin, Fondamenti ed esercizi di chimica generale e inorganica per i primi corsi universitari. --: Ed. Libreria Progetto, --.
  • R. H. Petrucci, W. S. Harwood, F. G. Herring, Chimica generale. --: Ed. Piccin, --. Cerca nel catalogo