First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
Faculty of Veterinary Medicine
VETERINARY MEDICINE
Course unit
VETERINARY GENERAL PATHOLOGY
AVP3052609, A.A. 2013/14

Information concerning the students who enrolled in A.Y. 2012/13

Information on the course unit
Degree course 5 years single cycle degree in
VETERINARY MEDICINE
MV0991, Degree course structure A.Y. 2011/12, A.Y. 2013/14
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination VETERINARY GENERAL PATHOLOGY
Website of the academic structure http://www.unipd.it/corsi/corsi-di-laurea/corsi-di-laurea-magistrale/medicina-veterinaria
Department of reference Department of Animal Medicine, Production and Health
Mandatory attendance
Language of instruction English
Branch LEGNARO (PD)
Single Course unit The Course unit CANNOT be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Lecturers
Teacher in charge VALENTINA ELENA GIUDITTA ZAPPULLI VET/03

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses VET/03 General Pathology and Veterinary Pathological Anatomy 6.0

Course unit organization
Period Second semester
Year 2nd Year
Teaching method frontal

Type of hours Credits Teaching
hours
Hours of
Individual study
Shifts
Practice 1.0 10 15.0 2
Lecture 5.0 50 75.0 No turn

Calendar
Start of activities 03/03/2014
End of activities 14/06/2014
Show course schedule 2019/20 Reg.2017 course timetable

Examination board
Board From To Members of the board
5 Commissione valida dall'A.A. 2016/2017 01/10/2016 30/09/2018 CASTAGNARO MASSIMO (Presidente)
ZAPPULLI VALENTINA ELENA GIUDITTA (Membro Effettivo)
CAVICCHIOLI LAURA (Supplente)
4 Commissione A.A. 2015/16 01/12/2015 30/09/2016 ARESU LUCA (Presidente)
ZAPPULLI VALENTINA ELENA GIUDITTA (Membro Effettivo)
CAVICCHIOLI LAURA (Supplente)
3 Commissione A.A. 2014/15 - validadal 02/03/2015 02/03/2015 30/11/2015 ARESU LUCA (Presidente)
ZAPPULLI VALENTINA ELENA GIUDITTA (Membro Effettivo)
CAVICCHIOLI LAURA (Supplente)
2 Commissione valida fino al 01/03/2015 01/12/2014 01/03/2015 ZAPPULLI VALENTINA ELENA GIUDITTA (Presidente)
ARESU LUCA (Membro Effettivo)
CAVICCHIOLI LAURA (Supplente)
1 Commissione A.A. 2013/14 01/01/2014 30/11/2014 ZAPPULLI VALENTINA ELENA GIUDITTA (Presidente)
ARESU LUCA (Membro Effettivo)
CAVICCHIOLI LAURA (Supplente)

Syllabus
Prerequisites: the requested knowledge regards anatomy, histology and phisioogy
Target skills and knowledge: Understand the four aspects of a disease process that form the core of pathology: its cause (etiology), the mechanisms of its development (pathogenesis), the structural alterations induced in the cell and organs of the body (morphologic changes), and the functional consequences of the morphologic changes. Student should pay attention on how cells and tissues respond to injury in a chronological sequence of events and to understand the complex interplay between the host defense mechanisms with the primary cause.
Examination methods: six written interim evaluations (10-15 MCQ) and final written examination (20 MCQ) and lab assessment at the end of each section with 5 MCQ and/or SAQ
Assessment criteria: students will have to demonstrate their ability in answering to short answer multiple choice questions showing their knowledge and ability to think
Course unit contents: The endogenous causes of diseases: DNA and gene expression. DNA repair mechanisms. Mendelian (monogenic, polygenic and chromosomal) diseases. Phenotypic consequences of mutations. Disorders with multifactorial inheritance. Non-mendelian genetic disorders (mitochondrial DNA, genomic imprinting, triplet-repeat disease, gonadic mosaicism).
Hexogen causes of diseases: Pathogenic mechanisms of ionizing and non-ionizing radiations. Thermal injuries (thermal burns, hyperthermia and heat stroke, hypothermia and freezing). Electrical injuries. Foreign bodies reactions. General principles of diseases caused by microorganisms (viruses, bacteria and parasites)
Cell degeneration and necrosis:
Acute and chronic inflammation: Tissue repair: Definition of tissue repair mechanisms. Control of normal cell proliferation. Stem-cell and differentiative tissue niches. Mechanisms of cell growth and differentiation: growth factors, their receptors and signal transduction pathways. Mechanisms of tissue regeneration: hepatic compensatory growth. Growth factors and the extracellular matrix. Angiogenesis. Mechanisms of wound healing (first and second intention). Tissue repair in specific tissues (bone, CNS) The pathology of tissue repair.
Amyloidoses: Definition and criteria of amyloid identification. Classification criteria of amyloidoses. Mechanisms of amyloidoses. Morphologic features of amyloidoses in animals.
Veterinary General Oncology: Definition and general features of neoplasia. Epidemiology of human and animal neoplasias. Geographic and environmental factors associated with neoplasias. Genetic and non genetic predisposition to neoplasia. Benign and malignant neoplasias. Criteria for classification of animal neoplasias. Gross and histologic features of animals neoplasias. Cell kinetic factors. Biology of neoplastic growth. Molecular bases of neoplasia. Clonal origin and progression of neoplasia. Neoplastic progression. Essential molecular changes for neoplastic progression: self-sufficiency in growth signals (oncogenes), insensitivity to growth inhibitory signals (tumor suppressor genes), evasion of apoptosis, DNA repair defects and genomic instability, limitless replicative potential, sustained angiogenesis, invasion and metastasis. Pathways of metastatic spread. Gatekeepers and caretakers genes. Oncofetal antigens. Tumor immunity. Local and systemic effects of neoplasia. Paraneoplastic syndromes. Neoplastic cachexia. Acute tumor lyses syndrome. Grading and staging of tumors. Mechanisms in multidrug resistance. Carcinogenic agents. Chemical carcinogenesis: initiators and promoters. Mechanisms in viral oncogenesis.
Hemodynamic disorders: Control of extracellular fluids and mechanisms of edema formation. Hyperemia and congestion. Hemorrhages. Haemostatic process. Pro-thrombotic and anti-thrombotic activity of endothelial cells. Platelets. The clotting system. Hemorrhagic disorders. The fibrinolytic system. Disseminated intravascular coagulation (DIC). Emboli and embolisms. Ischemia and infarctions. Shock.
Immunopathology: Atopy and the main immunomediated allergic diseases. Reactions to non-microbic components. Hypersensitivity reactions
Planned learning activities and teaching methods: frontal lectures and practicals in necropsy lab
Additional notes about suggested reading: pathology website, gross samples



M.Donald McGavin e James F. Zachary: Patologia Generale Veterinaria. Masson, 2008.
Textbooks (and optional supplementary readings)
  • James F. Zachary M.Donald McGavin, Pahologic Basis of Veterinary Disease. --: --, --.
  • V. Kumar, A. K. Abbas e N. Fausto, Robbins and Cotran Pathological Basis of Disease. --: Elsevier Saunders, --.