First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
Faculty of Veterinary Medicine
VETERINARY MEDICINE
Course unit
GENERAL PHARMACOLOGY, TOXYCOLOGY AND PHARMACOVIGILANCE
MVL1001707, A.A. 2013/14

Information concerning the students who enrolled in A.Y. 2011/12

Information on the course unit
Degree course 5 years single cycle degree in
VETERINARY MEDICINE
MV0991, Degree course structure A.Y. 2011/12, A.Y. 2013/14
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Number of ECTS credits allocated 5.0
Type of assessment Mark
Course unit English denomination GENERAL PHARMACOLOGY, TOXYCOLOGY AND PHARMACOVIGILANCE
Website of the academic structure http://www.unipd.it/corsi/corsi-di-laurea/corsi-di-laurea-magistrale/medicina-veterinaria
Department of reference Department of Animal Medicine, Production and Health
Mandatory attendance
Language of instruction Italian
Branch LEGNARO (PD)
Single Course unit The Course unit CANNOT be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Lecturers
Teacher in charge MAURO DACASTO VET/07
Other lecturers MERY GIANTIN VET/07
CLARA MONTESISSA

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses VET/07 Veterinary Pharmacology and Toxicology 5.0

Course unit organization
Period First semester
Year 3rd Year
Teaching method frontal

Type of hours Credits Teaching
hours
Hours of
Individual study
Shifts
Practice 1.0 10 15.0 2
Lecture 4.0 40 60.0 No turn

Calendar
Start of activities 01/10/2013
End of activities 25/01/2014
Show course schedule 2019/20 Reg.2017 course timetable

Examination board
Board From To Members of the board
5 Commissione valida dall'a.a. 2016/17 01/12/2016 30/11/2020 DACASTO MAURO (Presidente)
GIANTIN MERY (Membro Effettivo)
CAPOLONGO FRANCESCA (Supplente)
4 Commissione A.A. 2015/16 01/12/2015 30/11/2016 DACASTO MAURO (Presidente)
GIANTIN MERY (Membro Effettivo)
CAPOLONGO FRANCESCA (Supplente)
3 Commissione A.A. 2014/15 01/12/2014 30/11/2015 DACASTO MAURO (Presidente)
GIANTIN MERY (Membro Effettivo)
2 Commissione A.A. 2013/14 01/01/2014 30/11/2014 DACASTO MAURO (Presidente)
MONTESISSA CLARA (Membro Effettivo)
CAPOLONGO FRANCESCA (Supplente)
GIANTIN MERY (Supplente)
01/10/2009 31/12/2013 DACASTO MAURO (Presidente)
MONTESISSA CLARA (Membro Effettivo)
GIANTIN MERY (Supplente)

Syllabus
Prerequisites: Knowledge and expertise about either classification, form, structure, functions and illness of animals than related bio-molecular mechanisms

Required foundation courses: Veterinary General Pathology
Target skills and knowledge: Basic knowledge about veterinary pharmacokinetic and pharmacodynamic; factors contributing to drug (xenobiotic) response; species-differences in kinetic behavior of veterinary drugs and kinetic-dynamic aspects of drug-drug interactions; basic elements useful for the risk assessment of veterinary drugs in food-producing animals.
Basic knowledge about molecular and cellular and target-organ mechanisms of toxicity, including mutagenesis, carcinogenesis and reproductive toxicology
Examination methods: Oral final exam
Assessment criteria: Evaluation of the acquired knowledge about specific arguments; the student’s capability to discuss and solve specific problems and make by itself intra- and inter-disciplinary connections; the use of a specific scientific language
Course unit contents: General and Molecular Pharmacology and Toxicology (4 UFC)

Module program
Pharmacokinetics. Routes of administration. Absorption and passage through cellular membranes. Distribution. Drug metabolism Excretion.
Pharmacodynamics. Receptors and xenobiotic mechanisms of action.
Veterinary pharmacy. Veterinary pharmaceutical preparations.
Factors modulating drug response. Factors modulating drug efficacy.
General toxicology. Basic concepts. Acute, subacute and chronic toxicity. Cellular transport and accumulation of toxic compounds. Bioactivation.
Molecular and cellular toxicology. Oxidative stress. Disruption of calcium homeostasis and cellular energy production. Impairment of cellular cycle. Cell death (brief description of apoptotic and necrotic cell death). Covalent binding. Inactivation of specific enzymes and proteins. Toxicity mediated by nuclear receptors. Brief outlines of mutagenesis, carcinogenesis and reproductive toxicology.
Target organ toxicology. Outlines of immunotoxicology, hematotoxicity, endocrine system toxicity, hepatotoxicity, nephrotoxicity, neurotoxicity, inhalatory toxicology, skin toxicology.
Lab sessions: determination of a cytochrome P450-dependent drug metabolizing enzyme catalytic activity. Insecticides modulation of serum acetylcholinesterase enzymatic activity Virtual laboratories: Reading and critical discussion of a scientific article concerning veterinary pharmacology or toxicology

Drug surveillance (1 UFC)

Module program
Main pharmacokinetic parameters used for the evaluation of dosage schedule and compartmental and non compartmental mathematical models adopted
Drug/drug interaction: kinetic and dynamic aspect
Risk assessment of veterinary drug in food producing species. Regulation EC 2377/90, MRL and withdrawal time assessment

Lab sessions: calculation of main pharmacokinetic parameters from in vivo experimental data. Assessment of withdrawal time from in vivo residue depletion data. Reading and critical discussion of a scientific article concerning veterinary pharmacokinetics
Planned learning activities and teaching methods: Altogether, the course includes:
40 hours of frontal teaching
10 hours of practicals and hands on teaching
1 round of supplementary practicals and hands on teaching
Additional notes about suggested reading: Microsoft Power Point slide presentations are available on Moodle platform (https://elearning.unipd.it/scuolaamv/).

Consulting hour: by appointment with the lecturer
Textbooks (and optional supplementary readings)
  • Carli S., Ormas P., Re G., Soldani G., Farmacologia veterinaria. --: Idelson-Gnocchi Editore, 2009. ISBN 978-88-7947-484-9
  • Boelsterli U.A, Mechanistic toxicology. --: Taylor & Francis, 2003. ISBN 978-88-7947-484-9 Cerca nel catalogo
  • Nebbia C., Residui di farmaci e contaminanti ambientali nelle produzioni animali. --: EDISES, --. ISBN 978-88-7959-481-3 Cerca nel catalogo
  • Dolara, P., TOX – Lezioni di Tossicologia. --: Firenze University Press, 2006. ISBN 88-8453-412-7 Cerca nel catalogo