CANTON MARCELLA

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Ca811f55654af64b34198f780ef45fc9
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Structure Department of Biomedical Sciences
Telephone 0497923236
Qualification Ricercatore universitario confermato
Scientific sector BIO/10 - BIOCHEMISTRY
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Office hours
Monday from 10:00 to 12:00 VIMM, Via Orus, 2, Padova Si prega di inviare una mail entro venerdi della settimana precedente per avere conferma
(updated on 19/04/2018 12:44)

Curriculum Vitae
Current status: Research Assistant in Biochemistry (SSD BIO/10) in the Department of Biomedical Sciences, Faculty of Pharmacy (University of Padova)

1991: Graduated in Pharmaceutical Chemistry, University of Padova (110/110 cum laude).
1995: Ph.D. in Molecular and Cellular Biology and Pathology, Department of Biomedical Sciences, University of Padova
2006: Research Assistant in Biological Chemistry of the Faculty of Pharmacy, University of Padova

Research activity:
1989: C.E.E Erasmus Project fellowship at the Dept. of Organic Chemistry, University of Newcastle upon Tyne (UK); 1991/1995: PhD Training in Molecular and Cellular Biology and Pathology, University of Padova (tutor: Prof. Azzone) on the mechanisms of energy conversion in mitochondria and their alterations due to anahesthetics or hyperthyroidism; 1996/1997: research activity in the Laboratory of Biochemical Microbiology at GlaxoWellcome-Verona; 1997/2003: Post-doc fellowships, Dept of Biological Chemistry, University of Padova (supervisor: Prof Di Lisa). Study of the relationships between mitochondrial dysfunction and cell death; 1999: Dr. J. Van Eyk post-doctoral fellowship, Dept. of Physiology, Queen’s University, Kingston, Canada. Collaborative study on the identification of the oxidative modifications of the myofibrillar proteins; 2003/2005: post-doctoral fellowship FIRB-MIUR project n. RBAU0138CH, Dept. of Biological Chemistry, University of Padova (supervisor: Prof Di Lisa).
Research interest: oxidative modifications of myofibrillar proteins in ischemic myocardium and muscular dystrophy along with the mitochondrial sources of ROS.

Fundings:
2006-08: Responsible of the Ateneo Projects (Padova University).
2009-10: Responsible of a research grant from the Association francaise contre les myopathies
2009-11: Coordinator of the PRIN project: Role of monoamine oxidases and mitochondrial oxidative stress in the pathogenesis of muscular dystrophies and cardiac injury
2011-13: Responsible of a Junior fellowship (Padova University).
2014-2016: Co-responsible of a research sponsored by ZambonGroup
2018-2019: Responsible of a research grant from the Institute of Reseach Pediatric (IRP), Padova

Lecturer's Curriculum (PDF): CA811F55654AF64B34198F780EF45FC9.pdf

Publications
Ten selected publications

1. Nogara L, Naber N, Pate E, Canton M, Reggiani C, Cooke R (2016). Piperine's mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle Proc Natl Acad Sci U S A 113(46):13009-13014.
2. Sorato E, Menazza S, Zulian A, Sabatelli P, Gualandi F, Merlini L, Bonaldo P, Canton M, Bernardi P, Di Lisa F. (2014) Monoamine oxidase inhibition prevents mitochondrial dysfunction and apoptosis in myoblasts from patients with collagen VI myopathies. Free Radic Biol Med, 10, 40-47.
3. Canton M, Menazza S, Sheeran F L, Polverino De Laureto P, Di Lisa F, And Pepe S (2011). Oxidation of myofibrillar proteins in human heart failure. J Am Coll Cardiol, 57 (3) 300-309.
4. Menazza S, Blaauw B, Tiepolo T, Toniolo L, Braghetta P, Spolaore B, Reggiani C, Di Lisa F, Bonaldo P, Canton M. (2010). Oxidative stress by monoamine oxidases is causally involved in myofiber damage in muscular dystrophy. Hum Mol Genet, 19; 4207-4215.
5. Heusch P1, Canton M1, Aker S, Van De Sand A, Konietzka I, Rassaf T, Menazza S, Brodde O, Di Lisa F, Heusch G, Schulz R (2010). The contribution of reactive oxygen species and p38 mitogen activated protein kinase to myofilament oxidation and progression of heart failure in rabbits. Br J Pharmacol, 160 (6) 1408-1416. 1co-first
6. Caffieri S, Di Lisa F, Bolesani F, Facco M, Semenzato G, Dall'Acqua F, Canton M. (2007) The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapy. Blood 109 (11), 4988-94.
7. Canton M, Skyschally A, Menabo R, Boengler K, Gres P, Schulz R, Haude M, Erbel R, Di Lisa F, Heusch G. (2006) Oxidative modification of tropomyosin and myocardial dysfunction following coronary microembolization. Eur Heart J, 27 (7), 875-81.
8. Chilin A, Dodoni G, Frezza C, Guiotto A, Barbieri V, Di Lisa F, Canton M. (2005) 4-Hydroxymethyl-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one induces mitochondrial dysfunction and apoptosis upon its intracellular oxidation. J Med Chem. 48 (1), 192-9.
9. Canton M, Neverova I, Menabo R, Van Eyk J, Di Lisa F. (2004) Evidence of myofibrillar protein oxidation induced by post-ischemic reperfusion in isolated rat hearts. Am J Physiol Heart Circ Physiol, 286, H870-7.
10. Canton M, Caffieri S, Dall’Acqua F, Di Lisa F. (2002) PUVA-induced apoptosis involves mitochondrial dysfunction caused by the opening of the permeability transition pore. FEBS Lett 522 (1-3), 168-72.

List of taught course units in A.Y. 2018/19
Degree course code Degree course track Course unit code Course unit name Credits Year Period Teacher in charge
FA0243 000ZZ FAM1027417 BIOCHEMISTRY 6 1st Year Second semester MARCELLA CANTON