First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Agricultural Sciences and Veterinary Medicine
ANIMAL SCIENCE AND TECHNOLOGY
Course unit
BIOCHEMISTRY
AVP4068167, A.A. 2017/18

Information concerning the students who enrolled in A.Y. 2017/18

Information on the course unit
Degree course First cycle degree in
ANIMAL SCIENCE AND TECHNOLOGY (Ord. 2017)
IF0325, Degree course structure A.Y. 2017/18, A.Y. 2017/18
N0
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination BIOCHEMISTRY
Website of the academic structure http://www.agrariamedicinaveterinaria.unipd.it
Department of reference Department of Agronomy, Food, Natural Resources, Animals and the Environment
Mandatory attendance No
Language of instruction Italian
Branch LEGNARO (PD)

Lecturers
Teacher in charge ALESSANDRO NEGRO BIO/10

Integrated course for this unit
Course unit code Course unit name Teacher in charge
AVP4068165 GENERAL AND INORGANIC CHEMISTRY AND BIOCHEMISTRY ALESSANDRO NEGRO

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses BIO/10 Biochemistry 6.0

Mode of delivery (when and how)
Period First semester
Year 1st Year
Teaching method frontal

Organisation of didactics
Type of hours Credits Hours of
teaching
Hours of
Individual study
Shifts
Lecture 6.0 48 102.0 No turn

Calendar
Start of activities 02/10/2017
End of activities 19/01/2018

Examination board
Examination board not defined

Syllabus

Common characteristics of the Integrated Course unit

Prerequisites: No specific pass of these exams are required.
Target skills and knowledge: Through theoretical lectures and practical exercises, students will acquire know-how on fundamental chemistry. The resolution of numerical exercises will also make the student familiar with a scientific approach towards various topics. Gaining knowledge on the structure and function relationships in biological macromolecules, on the metabolism and the strategies of metabolic regulation.
Examination methods: The examination of students will be carried out through written tests accounting for numerical exercises and questions to be answered with a brief text production.
Assessment criteria: The examination of students will be carried out through written tests accounting for numerical exercises and questions to be answered with a brief text production.

Specific characteristics of the Module

Course unit contents: Carbohydrates: Monosaccarides, Disaccarides Sucrose e Lactose, Polysaccarides, Starch and Cellulose, Jaluronic acid, Heparin. Lipid: Fatty Acid, Triglicerides, Phosphoglicerides, colesterol, Biological Membrane. Amino acid e Protein Structure Amino acid classification. Primary, Secondary tertiary and Quaternary structure of proteins. Structure and function relationships in proteins and enzymes. Enzymes: mechanisms of catalysis, Michaelis-Menten kinetic, kinetic parameters, activators and inhibitors. Mechanisms of regulations. allosteric enzymes. Mioglobin, hemoglobin. Heme-globin bond, ossigenation, cooperativity, allosteric effectors and the Bohr effect.Bioenergetics.Carbohydrates and lipids metabolism: Transformation of energy during the metabolism. Esergonic and endergonic reactions, coupled reactions. Anabolism and catabolism. High energy compounds relevant to biochemistry. ATP. Substrate-level phosphorylation. The biological oxidation reactions. Structure and function of the respiratory chain. Oxidative phosphorylation in mitochondria and chemiosmotic mechanism of coupling. Physiologically relevant carbohydrates. Glucose metabolism and its regulation: glycolysis, pentose phosphate pathway, Krebs cycle. Gluconeogenesis. Glycogen metabolism. Physiologically relevant lipids. Lipid metabolism and its regulation: fatty acid biosynthesis, elongation, desaturation; Plasma lipoproteins: classification, structure, function, analysis. Digestion of lipids and chilomicrons formation. Metabolism of lipoproteins. Adipose tissue biochemistry, lipogenesis and lipolysis. fatty acids activation and oxidation. Mechanisms of fatty acid oxidation ketogenesis and ketone bodies utilization. Propionic acid utilization. Relationships between lipid and carbohydrate metabolism: role of the metabolic hormones and the tissues. Metabolism of proteins aminoacids Protein turnover. Alpha aminic nitrogen fate: deamination, transamination, glutamine synthesis, urea cycle. Catabolism of the carbon backbone of aminoacids. Hormones classification and general mechanisms of action. Cell surface and intracellular receptors. Intracellular messengers: cAMP and adenylate cyclase system, protein kinases and phosphatases, cGMP, phosphatidylinositols and Ca2+. Nitric oxide: synthesis and action mechanisms. Receptors with tyrosine kinase activity, insulin receptor. Steroid hormones receptors and action mechanisms.
Planned learning activities and teaching methods: Direct teaching activity, through the use of computer tools, the basic concepts of biochemistry. You will follow a step by step approach that provides an illustration of topics gradually more complicated formulas of the compounds to the structure of macromolecules to the relations of metabolism and its regulation pathways.
Additional notes about suggested reading: The presence of students during direct teaching activities are strictly recommended in order to acquire the material presented during lectures. At the end of each lectures the teaching will allow the students to access to slide material in pdf format.
Textbooks (and optional supplementary readings)
  • Jeremy M. Berg, John L. Tymoczko, Lubert Stryer, Biochimica. --: Zanichelli, 2012. Cerca nel catalogo
  • David L. Nelson, Michael M. Cox, I principi di biochimica di Lehninger. --: Zanichelli, 2010. Cerca nel catalogo
  • Fondamenti di biochimica, Donald Voet, Judith G. Voet, Charlotte W. Pratt. --: Zanichelli, 2013.