First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Science
Course unit
SC03101151, A.A. 2017/18

Information concerning the students who enrolled in A.Y. 2017/18

Information on the course unit
Degree course Second cycle degree in
SC1169, Degree course structure A.Y. 2015/16, A.Y. 2017/18
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination BIOINORGANIC CHEMISTRY
Department of reference Department of Chemical Sciences
Mandatory attendance No
Language of instruction Italian
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Teacher in charge DOLORES FREGONA CHIM/03

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses CHIM/03 General and Inorganic Chemistry 6.0

Mode of delivery (when and how)
Period Second semester
Year 1st Year
Teaching method frontal

Organisation of didactics
Type of hours Credits Hours of
Hours of
Individual study
Lecture 6.0 48 102.0 No turn

Start of activities 26/02/2018
End of activities 01/06/2018

Prerequisites: Inorganic chemistry skills are requested
Target skills and knowledge: The course is multidisciplinary and takes its place at the interface between the inorganic chemistry and biology and his purpose is to introduce the students to the principles of the coordination chemistry in the biological systems.
The course is divided in three parts: a) Principles of coordination chemistry. b) Study of the role of inorganic elements essential for the biological functions. c) The radioactivity: unstable nuclides and radioactive emissions, applications in medical diagnostics and therapy.
Examination methods: oral exam.
Assessment criteria: The assessment of the preparation of the student will be based on the critical learning and on the personal insight of the studied topics
Course unit contents: Fundamentals of Inorganic solution chemistry. Classification of metal ions and ligands: hard-soft, acid-base (HSAB) theory. Stability constants. Stabilization of oxidation states. Ligand field stabilization energy. Kinetics and mechanisms of reactions involving metal complexes. Electron-transfer reactions. Fundamentals of kinetics and thermodynamics (rate laws and rate constants). Equilibrium. Catalysis. Fundamentals of biochemistry (biological ligands, nucleotides, proteins). Metal uptake and transmembrane ion transport. Transport and storage in vivo. Metalloproteins and metalloenzymes( oxygen carriers, hydrolases, hydro-lyases). Redox chemistry (prosthetic centers, cofactors, coenzymes, electron-transfer pathways in respiratory metabolism).
Metal complexes as diagnostic and therapeutic agents.
Radioactivity: types of radioactive decay, radioactive decay rates, the chart of the nuclides, radiocarbon dating, applications of radioactivity in medicine.
Planned learning activities and teaching methods: The lectures will be held with the support of slides.
Students are invited to be present during the lectures and take notes as the existing texts are very wide and dispersive and should serve only as a possible deepening of the topics covered in the classroom.
Additional notes about suggested reading: The slides of the lectures will be made available to students.
Textbooks (and optional supplementary readings)
  • J.A. Cowan, Inorganic Biochemistry, an introduction.. --: Wiley-VCH,, --. Cerca nel catalogo
  • M. R. Roat-Malone, Bioinorganic chemistry: a short course.. --: Wiley Interscience, --. Cerca nel catalogo
  • I. Bertini, H. B. Gray, E. I Stiefel, J. S. Valentine, Biological Inorganic Chemistry, structure and Reactivity.. Sausalito,California.: University Science Books, --. Cerca nel catalogo
  • S. J. Lippard, J. M. Berg, Principles of Bioinorganic Chemistry. Mill Valley, California: Ed.University Science Books, --. Cerca nel catalogo