First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
PHARMACEUTICAL BIOTECHNOLOGIES
Course unit
PHARMACEUTICAL NANOTECHNOLOGY
MEP5072657, A.A. 2017/18

Information concerning the students who enrolled in A.Y. 2017/18

Information on the course unit
Degree course Second cycle degree in
PHARMACEUTICAL BIOTECHNOLOGIES
ME2193, Degree course structure A.Y. 2015/16, A.Y. 2017/18
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Number of ECTS credits allocated 8.0
Type of assessment Mark
Course unit English denomination PHARMACEUTICAL NANOTECHNOLOGY
Department of reference Department of Pharmaceutical and Pharmacological Sciences
Mandatory attendance
Language of instruction English
Branch PADOVA
Single Course unit The Course unit CANNOT be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Lecturers
No lecturer assigned to this course unit

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses CHIM/09 Applied Technological Pharmaceutics 8.0

Mode of delivery (when and how)
Period Second semester
Year 1st Year
Teaching method frontal

Organisation of didactics
Type of hours Credits Hours of
teaching
Hours of
Individual study
Shifts
Lecture 8.0 64 136.0 No turn

Calendar
Start of activities 26/02/2018
End of activities 01/06/2018

Syllabus
Prerequisites: Basic knowledge and concepts of organic chemistry, physics, biology.
Target skills and knowledge: i) information concerning the different types of NPs used for drug- and gene delivery in pharmaceutical sciences and biomedical applications
ii) knowledge concerning the dependency of the properties of the NPs on their molecular building blocks
iii) knowledge about the different types of technologies and equipment used for the characterization of the NPs in nanoscale
iv) hans-on case studies and applications of the NPs for drug and gene delivery
v) understanding of the use of the different types of nanotechnological analysis and devices for the characterization of the NPs and their interactions with small drugs, biomolecules and cells.
vi) Understand critically the scientific literature on a specific topic.
vii) Communication skills on scientific topic for public speech
Examination methods: small group activities and lecture set up based on critical understanding and description of 15 scientific publications in the field of Pharmaceutical Nanotechnology with open questions along discussion.
Assessment criteria: critical thinking of the student, communication skill and in depth scientific knowledge concerning selected topics for lecture set up.
Course unit contents: Lectures will be divided in two sections. The first part will introduce the different types of nanoparticle (NP) formulations used for drug and gene delivery, and the second part will deal with the different type of the instrumentation and detection technologies used in pharmaceutical nanotechnology.
NPs in drug and gene delivery: The NPs discussed in class will be polymeric nanoparticles, liposomes and self assembly, nanomaterials and their biocombability. Case studies will be described including different types of gold NP integrated into liposome for external triggering and drug release and poly--amine and poly-L-lactide NP for gene delivery. These case studies will refer to the research performed and published at the international pre-reviewed journals by VIP and her colleagues. In addition the planning of the construction of the different types of NPs, paying attention to the toxicity issues and advantage of external triggering will be discussed at the first part of the lectures of the course. Extracellular vesicles will be shortly introduced and some the new phenomena of their use both in drug delivery and biomarker analysis were lectured.
Pharmaceutical detection technologies and instrumentation in nanotechnology: detection technologies and instrumentation will be discussed along the lectures, by keeping the focus at the pharmaceutical applications. The equipment and technologies covered will include surface plasmon resonance (SPR), quartz crustal microbalance (QCM), atomic force - and scanning tunneling microscopies (AFM and STM), scanning electron- and cryo transmission –microscopies (SEM and GryoTM), and different UV-vis spectorcopies (IR, Raman, absortion, excitation, fluoresence and phosphorence) both steady state and time-resolved. In each of the technology presented an example and a case study was presented for the use and its application in pharmaceutical sciences.
Planned learning activities and teaching methods: The Pharmaceutical Nanotechnology course included following parts:
1. Lectures with case studies (56 hours)
2. Power point Nanoparticle seminar days; - presentations and opponents by students
3. Nanotechnology reports; - report writing, including also self – and colleagues evaluation by students
Textbooks (and optional supplementary readings)