First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
MEDICAL BIOTECHNOLOGIES
Course unit
NANOBIOTECHNOLOGY
MEO2045678, A.A. 2017/18

Information concerning the students who enrolled in A.Y. 2017/18

Information on the course unit
Degree course Second cycle degree in
MEDICAL BIOTECHNOLOGIES
ME1934, Degree course structure A.Y. 2012/13, A.Y. 2017/18
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Degree course track MEDICAL BIOTECHNOLOGIES [002PD]
Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination NANOBIOTECHNOLOGY
Website of the academic structure https://www.medicinamolecolare.unipd.it
Department of reference Department of Molecular Medicine
Mandatory attendance No
Language of instruction English
Branch PADOVA
Single Course unit The Course unit CANNOT be attended under the option Single Course unit attendance
Optional Course unit The Course unit is available ONLY for students enrolled in MEDICAL BIOTECHNOLOGIES

Lecturers
Teacher in charge RAFFAELLA SIGNORINI CHIM/02
Other lecturers SABRINA ANTONELLO CHIM/02
MARIO BORTOLOZZI FIS/07

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses CHIM/02 Physical Chemistry 4.0
Core courses FIS/07 Applied Physics (Cultural Heritage, Environment, Biology and Medicine) 2.0

Mode of delivery (when and how)
Period Second semester
Year 1st Year
Teaching method frontal

Organisation of didactics
Type of hours Credits Hours of
teaching
Hours of
Individual study
Shifts
Lecture 6.0 48 102.0 No turn

Calendar
Start of activities 26/02/2018
End of activities 01/06/2018

Examination board
Examination board not defined

Syllabus
Prerequisites: No prerequisite
Target skills and knowledge: The nanobiotechnology course is formed by two units: (i) Physical chemistry of nanosystems and (ii) Bio-imaging. Aim of the first unit is to give basic knowledge on the physical and chemical properties of materials with nanometric dimensions that can be valuable for the development of sensors, diagnostic tools and drug carriers. These basic concepts will introduce the student to the basic properties of different nanomaterials, how to characterize them, and the way in which they can be exploited in the field of bio-medicine. The second part of the class is devoted to an in depth description of fluorescence microscopy techniques. Microscopy is largely used in the field of bio-medicine to observe and study the properties of different systems: from simple cell culture to in-vivo tissues. The student will learn the physical concepts on which fluorescence microscopy is founded, as well as the most recent methodologies in this field.
Examination methods: Two written exams with open question for each units, and an oral exam, when asked by the student, only for unit (i).
Assessment criteria: The evaluation will consider the student capability to summarize in a clear and synthetic way the concepts learned in the class, with particular attention to the development of a critical attitude towards the notions learned in the course.
Course unit contents: Unit (i) Physical Chemistry of the Nanosystems:
Physical and chemical properties of bulk and nanomaterials: highlights on the electronic structure of atoms, molecules, metallic, semiconductors and insulating materials. Intermolecular forces and molecular recognition, surface interactions, molecular self-assembly. Structure and properties of metal, semiconductor and oxide nanoparticles.
Highlights on the techniques used to characterize nanomaterials:
X-ray diffraction, Optical and electronic microscopy, Scanning Probe Microscopy: STM and AFM, Absorption and emission spectroscopy, IR and Raman spectroscopy, Micro-raman and SERS.
Highlights on the use of nanoparticles and macromolecular compounds in the bio-medical field:


Unit (ii) Bio-Imaging

Electromagnetic waves
Refractive index
Propagation laws
Optical systems and image formation
Fluorescence: molecular apspects
Conventional fluorescence microscope
Point Spread Function (PSF) and resolving power of the microscope
Confocal Microscopy
Multiphoton Microscopy
STED Microscopy
Ca2+ Imaging
FRET
FRAP
Planned learning activities and teaching methods: 4 CFU (32 hours) frontal lectures for unit (i) and 2 CFU (16 hours) frontal lectures for unit (ii). The frontal lectures will be used to give a description of the physcial and chemical properties of nanosystems and advanced technologies of fluorescence microscopy making use of many examples gathered from recent literature.
Additional notes about suggested reading: Teacher lecture notes
Papers suggested by the teacher
All books listed in the following are suggested only for consultation.
Textbooks (and optional supplementary readings)
  • L. Cademartiri and G. A Ozin, Concepts of nanochemistry. --: Wiley-VCH, 2009. Cerca nel catalogo
  • P.W. Atkins and J. de Paula, Concepts of physcial Chemistry. --: Oxford University Press, --. All editions Cerca nel catalogo