First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
MEDICAL BIOTECHNOLOGIES
Course unit
LABORATORY MEDICINE TECHNOLOGIES AND MOLECULAR DIAGNOSTICS
MEO2045681, A.A. 2017/18

Information concerning the students who enrolled in A.Y. 2017/18

Information on the course unit
Degree course Second cycle degree in
MEDICAL BIOTECHNOLOGIES
ME1934, Degree course structure A.Y. 2012/13, A.Y. 2017/18
N0
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Degree course track MOLECULAR MEDICINE [001PD]
Number of ECTS credits allocated 14.0
Type of assessment Mark
Course unit English denomination LABORATORY MEDICINE TECHNOLOGIES AND MOLECULAR DIAGNOSTICS
Department of reference Department of Molecular Medicine
Mandatory attendance No
Language of instruction English
Branch PADOVA
Single Course unit The Course unit CANNOT be attended under the option Single Course unit attendance
Optional Course unit The Course unit is available ONLY for students enrolled in MEDICAL BIOTECHNOLOGIES

Lecturers
Teacher in charge ARIANNA LOREGIAN MED/07
Other lecturers LUISA BARZON MED/46
LUISA BARZON MED/46

Mutuating
Course unit code Course unit name Teacher in charge Degree course code
MEO2045681 LABORATORY MEDICINE TECHNOLOGIES AND MOLECULAR DIAGNOSTICS ARIANNA LOREGIAN ME1934

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Educational activities in elective or integrative disciplines MED/07 Microbiology and Clinical Microbiology 4.0
Educational activities in elective or integrative disciplines MED/46 Laboratory Medicine Techniques 4.0
Core courses MED/07 Microbiology and Clinical Microbiology 6.0

Mode of delivery (when and how)
Period First semester
Year 1st Year
Teaching method frontal

Organisation of didactics
Type of hours Credits Hours of
teaching
Hours of
Individual study
Shifts
Lecture 14.0 112 238.0 No turn

Calendar
Start of activities 02/10/2017
End of activities 19/01/2018

Syllabus
Prerequisites: The course requires good knowledge of biochemistry, cellular biology, microbiology, genetics, and molecular biology.
Target skills and knowledge: To gain knowledge of several classical and modern technologies and procedures currently used in the laboratory medicine and molecular diagnostics.
Examination methods: The exam will consist in a written test.
Assessment criteria: Accuracy and completeness of test answers. Appropriateness of language.
Course unit contents: Molecular biology techniques based on nucleic acid amplification or hybridization. Techniques to study DNA methylation. Techniques for diagnosis of pathogenic microbes not based on molecular biology (isolation and identification of pathogenic bacteria, techniques for virological diagnosis not based on molecular biology). Therapeutic Drug Monitoring, TDM (pharmacokinetic parameters usually determined for TDM, methods for dosing drugs in biological samples, HPLC methods for dosing drugs, applications of TDM in diagnosis, practical lessons in a laboratory diagnostic unit performing TDM). Techniques to test the sensibility in vitro of microbial pathogens to drugs. Pharmacogenetics (basic principles and applications for diagnostic purposes, enzymes involved in drug metabolism, most common single nucleotide polymorphisms (SNPs) in the enzymes involved in drug metabolism and their pathogenetic relevance; microchips for diagnosis of these SNPs). Next-generation sequencing technologies, whole genome sequencing, metagenomics, paleogenomics, transcriptomics, metatranscriptomics, epigenomics, ChIP-sequencing, microbiome analysis. Validation and verification of diagnostic methods. Quality assurance in the clinical laboratory. Presentation and discussion of scientific articles describing recent and novel diagnostic techniques and their application.
Planned learning activities and teaching methods: The course consists of lectures and some practical lessons.
Additional notes about suggested reading: Slides of the lessons and bibliographic material provided by teachers.
Textbooks (and optional supplementary readings)