First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Engineering
Course unit
INP4062715, A.A. 2017/18

Information concerning the students who enrolled in A.Y. 2017/18

Information on the course unit
Degree course Second cycle degree in
IN0532, Degree course structure A.Y. 2011/12, A.Y. 2017/18
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination BIOMATERIALS AND BIOLOGICAL TISSUES
Department of reference Department of Information Engineering
Mandatory attendance No
Language of instruction Italian
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Teacher in charge ANDREA BAGNO ING-IND/34

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses ING-IND/34 Industrial Bioengineering 6.0

Mode of delivery (when and how)
Period First semester
Year 1st Year
Teaching method frontal

Organisation of didactics
Type of hours Credits Hours of
Hours of
Individual study
Lecture 6.0 48 102.0 No turn

Start of activities 25/09/2017
End of activities 19/01/2018

Prerequisites: Elements of chemistry, organic chemistry, biochemistry and biomaterials.
Target skills and knowledge: Students are expected to understand:
1) processes that govern the interactions between the surface of an implanted device and the surrounding biological environment;
2) methods to promote/improve those interactions;
3) recent applications of regenerative medicine for tissues/organs replacement.
Students are expected to perform a detailed and documented evaluation about the materials used for the construction of prosthetic devices, also obtained with the tissue engineering techniques.
Examination methods: 2 written examinations in progress, oral examination in the official sessions
Assessment criteria: Students' preparation will be assessed on the basis of their ability to critically discuss the topics covered during the course.
Course unit contents: Introduction to the course. General concepts. Modern approach to the study of biomaterials. Regenerative medicine. Tissue engineering: preliminary considerations.
Examples of tissue replacement: skin, cartilage, blood vessels, heart valves.
Metallic materials: general aspects and applications.
Polymeric biomaterials: general aspects and applications.
Ceramic biomaterials: general aspects and applications.
Composite biomaterials: general aspects and applications.
Interaction between proteins and surface. Protein adsorption.
Kinetic factors and mass transport governing protein adsorption.
Interactions between biomaterials and blood. Composition of the blood. Origin and role of blood cells. The process of coagulation: role of platelets.
The intrinsic and extrinsic blood coagulation process. Anticoagulants. The design of biomaterials and biomedical devices as a function of the interaction with blood: the case of vascular grafts, oxygenators, ventricular assist devices, heart valves.
The process of inflammation: redness, swelling, pain and heat. Role of non-lymphoid leukocytes. Tissue macrophages, neutrophils and monocyte-macrophages.
Chemotaxis. Phagocytosis. Opsonization. Diapedesis. Infection: immediate and delayed.
Kinetic model of platelet adhesion.
Immune system. Immunity: innate and acquired. Humoral and cell-mediated. Role of B lymphocytes and T-lymphocytes. Immunogens, antigens and antibodies. The complement system.
Wound healing. Tissues and extra-cellular matrix. Hemostasis and inflammation. Proliferative phase. Outside-in and inside-out signaling. Angiogenesis. Granulation tissue and scar tissue. Remodeling.
Chronic wounds. Using hyaluronic acid in healing ulcers.
Healing around an implant device. Frustrated phagocytosis. Formation of fibrotic capsule in relation to the properties of the device. Complications. Cytotoxicity and immunotoxicity.
Carcinogenesis due to foreign body.
Biochemical functionalization: adsorption of biomolecules, covalent bond and release from carrier.
Experimental work for the determination osteoblasts adhesion in vitro and in vivo.
Biomolecules of interest, peptide mimicry. Cell-cell adhesion, cell-ECM adhesion. Functions of cell membrane. Cell membrane proteins. Functions and composition of the ECM. ECM proteins.
Growth factors: case studies.
Biocompatibility assessment.
The reconstruction of tissue engineered heart valves.
Mass transport phenomena in biological systems. Oxygen consumption and transport in biological systems. Michaelis-Menten’s equation. Henry's Law. Balance equation. Stokes-Einstein’s law. First and second Fick's laws. Thiele’s modulus.
Design of bio-artificial constructs extra-vascular implants. Diffusive-convective processes.
Krogh’s model.
Planned learning activities and teaching methods: The program will be conducted through traditional lectures and seminars.
The learning objectives will be achieved through the in class presentation and discussion of the topics covered by the program.
Additional notes about suggested reading: Supplementary teaching material will be provided through Moodle.
Textbooks (and optional supplementary readings)
  • Carlo Di Bello e Andrea Bagno, Biomateriali (seconda edizione). Bologna: Patron Editore, 2016.
  • Carlo Di Bello e Andrea Bagno, Interazioni tra biomateriali e tessuti. Bologna: Patron Editore, 2009. Cerca nel catalogo
  • Riccardo Pietrabissa, Biomateriali per protesi e organi artificiali. Bologna: Patron Editore, 1996. Cerca nel catalogo
  • James F. Shackelford, Scienza e ingegneria dei materiali. --: Pearson Prentice Hall, 2009. Cerca nel catalogo
  • Leone Corradi dall’Acqua, Meccanica delle strutture (volume 1). --: McGraw-Hill, 1992.