First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Science
Course unit
SC01110895, A.A. 2017/18

Information concerning the students who enrolled in A.Y. 2016/17

Information on the course unit
Degree course Second cycle degree in
SC1731, Degree course structure A.Y. 2014/15, A.Y. 2017/18
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination BIOCHEMICAL REACTORS
Website of the academic structure
Department of reference Department of Biology
Mandatory attendance
Language of instruction Italian
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Teacher in charge ELEONORA SFORZA

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Other -- -- 3.0
Core courses ING-IND/25 Chemical Plants 2.0
Core courses ING-IND/34 Industrial Bioengineering 1.0

Mode of delivery (when and how)
Period First semester
Year 2nd Year
Teaching method frontal

Organisation of didactics
Type of hours Credits Hours of
Hours of
Individual study
Laboratory 1.0 16 9.0 No turn
Lecture 5.0 40 85.0 No turn

Start of activities 02/10/2017
End of activities 19/01/2018

Examination board
Board From To Members of the board
5 REATTORI BIOCHIMICI 2016-2017 01/10/2016 30/11/2017 BERTUCCO ALBERTO (Presidente)
SFORZA ELEONORA (Membro Effettivo)
SPILIMBERGO SARA (Membro Effettivo)

Prerequisites: None.
Target skills and knowledge: This course is headed to provide the students with the basic knowledge regarding the features and operation characteristics of industrial bioreactors and fermentors, both qualitatively and quantitatively.
Examination methods: Oral exam, that can be taken only after the fulfillment of laboratory requirements.
Assessment criteria: The achievement of the skills listed above will be the matter of the evaluation step.
Course unit contents: Material and Energy conservation balance fundamentals, and their application to industrial block flow diagrams. Basics of biochemical reactor engineering, and schemes for both enzymatic and biological reactors. Biochemical kinetics evaluation: models, experimental measurements and kinetic parameter correlation.
Immobilized enzymes and cell technology. Effect of immobilization on the reaction kinetics.
Modeling and simulation of biochemical reactors: Batch Reactor, Continuous Stirred Tank Reactor (CSTR), Plug Flow Reactor (PFR), Dispersed Flow Reactor, Recycle Reactor, Attached growth reactor, Bubble reactor, Trickle-bed reactor. Processes with thickening and recycling of biomass.
Process control in bioreactors.
Industrial examples: production of bioethanol from starch, biological wastewater treatment with activated sludge, large scale microalgae cultivation.
Computer calculations: Excel simulation of a bioreactor.
Laboratory experiments: E.coli fermentation in pilot reactor. Measurement and comparison of biomass productivity between a batch reactor and a continuous perfectly mixed reactor. The reacor used is equipped with sensors for monitoring, and temperature and pH are automatically controlled. Also the feed flowrates of liquid and gases are controlled. The students are required to thoroughly understand and actively contribute to the course of the experimental runs, by setting the values of operating variables, starting up the equipment, inoculating bacteria and measuring the amount of the biomass produced along with time.
Planned learning activities and teaching methods: Classroom lectures and laboratory activities.
Additional notes about suggested reading: lecture notes delivered directly by the teacher
Textbooks (and optional supplementary readings)