First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Science
SANITARY BIOLOGY
Course unit
BIOCHEMISTRY OF DISEASES
SCP5073118, A.A. 2017/18

Information concerning the students who enrolled in A.Y. 2016/17

Information on the course unit
Degree course Second cycle degree in
SANITARY BIOLOGY
SC1177, Degree course structure A.Y. 2008/09, A.Y. 2017/18
N0
bring this page
with you
Number of ECTS credits allocated 8.0
Type of assessment Mark
Course unit English denomination BIOCHEMISTRY OF DISEASES
Website of the academic structure http://biologiamolecolare.scienze.unipd.it/2017/laurea_magistrale_biologiasanitaria
Department of reference Department of Biology
Mandatory attendance
Language of instruction English
Branch PADOVA
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Lecturers
Teacher in charge LUCA SCORRANO BIO/10
Other lecturers MARTA GIACOMELLO BIO/10

Mutuated
Course unit code Course unit name Teacher in charge Degree course code
SCP5073118 BIOCHEMISTRY OF DISEASES LUCA SCORRANO SC1175

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses BIO/10 Biochemistry 8.0

Mode of delivery (when and how)
Period First semester
Year 2nd Year
Teaching method frontal

Organisation of didactics
Type of hours Credits Hours of
teaching
Hours of
Individual study
Shifts
Laboratory 2.0 32 18.0 No turn
Lecture 6.0 48 102.0 No turn

Calendar
Start of activities 02/10/2017
End of activities 19/01/2018

Syllabus
Prerequisites: Biochemistry, Physiology and Pathology
Target skills and knowledge: This course aims at giving to the student an overview of the frontier topics on the molecular and biochemical aspects of pathology. In particular, by using a combination of traditional class lectures, seminars, small groups tutorials, Journal Clubs and practicals, the student will acquire specific abilities on the topics discussed during the course.
Examination methods: Evaluation of the reports handled to the teachers during the course. A final written exam (multiple choice+small essays) might be foreseen under particular circumstances.
Assessment criteria: We will evaluate the individual contribution during the course (30%), the lab reports (30%), the essays produced during the course and the final exam (10%)
Course unit contents: 1. Introduction to the course

2. Mechanisms of protein homeostasis
3. Mechanisms of cellular ion homeostasis
4. Mechanisms of redox homeostasis and cellular bioenergetics
5. Biochemical mechanisms of reversible cellular damage
a. atrophy
b. hypertrophy
c. Metaplasia (EMT)
6. Biochemical mechanisms of irreversible cellular damage
a. apoptosis
b. necrosis
c. necroptosis
d. Autosis
7. Biochemical mechanisms of senescence and aging
8. Biochemical mechanisms of cell transformation and oncogenesis
9. Role of biochemistry in mitochondrial disease

These topics will be covered in specific workshops, Journal Clubs, lectures held by the teacher and by ad-hoc invited international experts.

Tutorials
Laboratory tutorials on biochemical assays of cell death and autophagy and on the analysis of mitochondrial dysfunction
Planned learning activities and teaching methods: Lectures and practicals
Additional notes about suggested reading: Articles and reviews that will be distributed
Textbooks (and optional supplementary readings)