First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
MEDICAL BIOTECHNOLOGIES
Course unit
PHARMACOLOGY AND MOLECULAR THERAPIES
MEO2045675, A.A. 2017/18

Information concerning the students who enrolled in A.Y. 2016/17

Information on the course unit
Degree course Second cycle degree in
MEDICAL BIOTECHNOLOGIES
ME1934, Degree course structure A.Y. 2012/13, A.Y. 2017/18
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Degree course track MEDICAL BIOTECHNOLOGIES [002PD]
Number of ECTS credits allocated 14.0
Type of assessment Mark
Course unit English denomination PHARMACOLOGY AND MOLECULAR THERAPIES
Department of reference Department of Molecular Medicine
Mandatory attendance No
Language of instruction English
Branch PADOVA
Single Course unit The Course unit CANNOT be attended under the option Single Course unit attendance
Optional Course unit The Course unit is available ONLY for students enrolled in MEDICAL BIOTECHNOLOGIES

Lecturers
Teacher in charge MARIA CRISTINA PAROLIN BIO/19
Other lecturers ANDREA CIGNARELLA BIO/14
ALFREDO GARZINO DEMO MED/07
MARTA TREVISAN

Mutuated
Course unit code Course unit name Teacher in charge Degree course code
MEO2045675 PHARMACOLOGY AND MOLECULAR THERAPIES MARIA CRISTINA PAROLIN ME1934

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Educational activities in elective or integrative disciplines BIO/14 Pharmacology 4.0
Core courses BIO/19 General Microbiology 4.0
Core courses MED/07 Microbiology and Clinical Microbiology 6.0

Mode of delivery (when and how)
Period First semester
Year 2nd Year
Teaching method frontal

Organisation of didactics
Type of hours Credits Hours of
teaching
Hours of
Individual study
Shifts
Lecture 14.0 112 238.0 No turn

Calendar
Start of activities 02/10/2017
End of activities 19/01/2018

Examination board
Examination board not defined

Syllabus
Prerequisites: Background knowledge in biomedical disciplines such as biochemistry, physiology, pathology, molecular biology, cell biology, microbiology.
Target skills and knowledge: Pharmacology: This course focuses on drug design & development. The main learning outcome is how to manage approaches to drug discovery, and establish safety and efficacy.
Molecular Therapies: This course will provide a broad and in-depth knowledge of basic concepts and innovative tools in the rapidly developing field of innovative molecular therapeutic approaches.
Examination methods: Pharmacology: Written test including open and multiple choice questions. Time: 1 hour. Extra books not allowed. Group work before test will be awarded extra marks according to content, focus, organization, style.
Molecular Therapies: Written test with open questions. Group discussion on selected topics will be taken into consideration for additional score.
Assessment criteria: Knowledge of topic; ability to argue and justify the decision-making process when required; structure of argument; scientific language and terminology skills.
Course unit contents: PHARMACOLOGY:
Origin of new drugs – Small molecules versus biopharmaceuticals; the drug discovery phase; preclinical development; clinical development
Pharmacokinetics – Physical processes underlying drug disposition; drug absorption and routes of administration; distribution of drugs in the body; special drug delivery systems; drug metabolism; drug and metabolite excretion; clinical pharmacokinetics: temporal characteristics of drug effects and relationship to the therapeutic window; first-order kinetics; effect of repeated dosing.
Pharmacogenetics and Pharmacogenomics – Individual variation in drug response: genetic factors; biomarkers as predictors of efficacy and safety; clinical validity and clinical utility of genomic biomarkers; moving from bench to bedside.
Biopharmaceuticals – Examples of therapeutic proteins; problems in manufacture; evolution of monoclonal antibodies; safety issues; pharmacokinetics and pharmacodynamics; antisense RNAs as drugs.
MOLECULAR THERAPIES:
Advanced molecular therapies: definition, advantages and main current limitations, ethical issues
Concepts and tools of gene and cell therapy
Delivery systems and therapeutic strategies for cell and gene therapy
Development and application of virus-based vectors: retroviruses, lentiviruses, adenoviruses, adeno-associated viruses, herpes simplex virus, alphaviruses
Oncolytic viruses for treatment of cancer
Application of gene therapy to non neoplastic disorders
Gene therapy approaches for HIV-1 infection
Intellectual property
A perspective on Biotech in Italy
Process of research and development
Pre clinical development
Clinical development
Opportunities: rare, neglected diseases. Orphan drugs
Opportunities: Biosimilars
Peptides as therapies
Nucleic acids as therapeutics/therapeutic targets
Delivery systems: Nanoparticles
Advances in the use of adult stem cells and induced pluripotent stem cells as “medicinal products” for therapies: stem cell-based therapies as “medicinal products” and manipulation according to the manufacture of biological medicinal products for human and defined conditions of good manufacturing practice (GMP).
Advances in corneal surgery and cell therapy: Challenges and perspectives for eye banks.
Limbal stem cells and clinical applications.
Gene editing strategies delivery technologies and platforms for genome editing: zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR–Cas9 system engineered nucleases to correct genetic defects and to cure chronic viral infections: design, mechanism of action, limitations and examples.
Planned learning activities and teaching methods: Classes, group work.
Additional notes about suggested reading: Students will receive lecture slides and review articles on selected topics.
A review of a general text of pharmacology/therapeutics and gene and cell therapy would be appropriate. No one single text is absolutely recommended. Suitable texts are indicated.
Textbooks (and optional supplementary readings)
  • Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor, Basic and Clinical Pharmacology. New York: 13 ed. McGraw-Hill Education, 2015. Cerca nel catalogo
  • Nancy Smyth Templeton, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies. --: Fourth Edition, CRC Press Taylor & Francis Group, 2015. Cerca nel catalogo