BIOCHEMISTRY OF DISEASES

Second cycle degree in SANITARY BIOLOGY

Campus: PADOVA

Language: English

Teaching period: First Semester

Lecturer: LUCA SCORRANO

Number of ECTS credits allocated: 8


Syllabus
Prerequisites: Biochemistry, Physiology and Pathology
Examination methods: Evaluation of the reports handled to the teachers during the course. A final written exam (multiple choice+small essays) might be foreseen under particular circumstances.
Course unit contents: 1. Introduction to the course

2. Mechanisms of protein homeostasis
3. Mechanisms of cellular ion homeostasis
4. Mechanisms of redox homeostasis and cellular bioenergetics
5. Biochemical mechanisms of reversible cellular damage
a. atrophy
b. hypertrophy
c. Metaplasia (EMT)
6. Biochemical mechanisms of irreversible cellular damage
a. apoptosis
b. necrosis
c. necroptosis
d. Autosis
7. Biochemical mechanisms of senescence and aging
8. Biochemical mechanisms of cell transformation and oncogenesis
9. Role of biochemistry in mitochondrial disease

These topics will be covered in specific workshops, Journal Clubs, lectures held by the teacher and by ad-hoc invited international experts.

Tutorials
Laboratory tutorials on biochemical assays of cell death and autophagy and on the analysis of mitochondrial dysfunction