PHARMACEUTICAL NANOTECHNOLOGY

Second cycle degree in PHARMACEUTICAL BIOTECHNOLOGIES

Campus: PADOVA

Language: English

Teaching period: Second Semester

Lecturer: -- --

Number of ECTS credits allocated: 8


Syllabus
Prerequisites: Basic knowledge and concepts of organic chemistry, physics, biology.
Examination methods: small group activities and lecture set up based on critical understanding and description of 15 scientific publications in the field of Pharmaceutical Nanotechnology with open questions along discussion.
Course unit contents: Lectures will be divided in two sections. The first part will introduce the different types of nanoparticle (NP) formulations used for drug and gene delivery, and the second part will deal with the different type of the instrumentation and detection technologies used in pharmaceutical nanotechnology.
NPs in drug and gene delivery: The NPs discussed in class will be polymeric nanoparticles, liposomes and self assembly, nanomaterials and their biocombability. Case studies will be described including different types of gold NP integrated into liposome for external triggering and drug release and poly--amine and poly-L-lactide NP for gene delivery. These case studies will refer to the research performed and published at the international pre-reviewed journals by VIP and her colleagues. In addition the planning of the construction of the different types of NPs, paying attention to the toxicity issues and advantage of external triggering will be discussed at the first part of the lectures of the course. Extracellular vesicles will be shortly introduced and some the new phenomena of their use both in drug delivery and biomarker analysis were lectured.
Pharmaceutical detection technologies and instrumentation in nanotechnology: detection technologies and instrumentation will be discussed along the lectures, by keeping the focus at the pharmaceutical applications. The equipment and technologies covered will include surface plasmon resonance (SPR), quartz crustal microbalance (QCM), atomic force - and scanning tunneling microscopies (AFM and STM), scanning electron- and cryo transmission –microscopies (SEM and GryoTM), and different UV-vis spectorcopies (IR, Raman, absortion, excitation, fluoresence and phosphorence) both steady state and time-resolved. In each of the technology presented an example and a case study was presented for the use and its application in pharmaceutical sciences.